Journal articles


Galina Kolesova, Alexander Stepanov, Galina Lebedeva, Oleg Demin. Application of different approaches to generate virtual patient populations for the quantitative systems pharmacology model of erythropoiesis. Journal of Pharmacokinetics and Pharmacodynamics. 2022. doi: 10.1007/s10928-022-09814-y


Evgeny Metelkin. Heta compiler: a software tool for the development of large-scale QSP models and compilation into simulation formats. JOSS: The Journal of Open Source Software. 2021. 6(67), 3708. doi: 10.21105/joss.03708.

Bloomingdale P., Karelina T., Cirit M., Muldoon SF., Baker J., McCarty W.J, Geerts H., Macha S. Quantitative systems pharmacology in neuroscience: Novel methodologies and technologies. CPT: Pharmacometrics Syst Pharmacology. 2021. doi: 10.1002/psp4.12607.

Karelina T., Lerner S., Stepanov A., Meerson M., Demin O. Monoclonal antibody therapy efficacy can be boosted by combinations with other treatments: predictions using an integrated Alzheimer's Disease Platform. CPT Pharmacometrics Syst Pharmacology. 2021. doi: 10.1002/psp4.12628.


Borisov I., Metelkin E. Confidence intervals by constrained optimization—An algorithm and software package for practical identifiability analysis in systems biology. PLoS Comput Biol 16(12): e1008495.


Stepanov A., Karelina T., Markevich N., Demin O., Nicholas T. A mathematical model of multisite phosphorylation of tau protein. PLOS ONE 13(3): e0194002. doi: 10.1371/journal.pone.0192519.