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Презентации и постеры

AAIC 2018, Chicago, IL, USA

  • Poster: Translational quantitative systems pharmacology model of tauopathies
    Authors: Tatiana Karelina and Alexander Stepanov
  • Poster: Description of different amyloid toxic species and pathology progression by mechanistic quantitative systems pharmacology model
    Authors: Tatiana Karelina, Alexander Stepanov and Alena Zhukova

PAGE 2018, Montreux, Switzerland

  • Poster: A semi-mechanistic model of targeted therapy for melanoma
    Authors: Dmitrii Shchelokov and Oleg Demin Jr
  • Poster: Simulations of tau-targeted therapies using quantitative systems pharmacology model of tau pathology
    Authors: Tatiana Karelina, Alexander Stepanov and Oleg Demin
  • Poster: Quantitative Systems Pharmacology Modeling of CAR-T Therapy and T Cell Engaging Bispecific Antibodies: B-cell Acute Lymphoblastic Leukemia Case Study
    Authors: Oleg Demin Jr and Antonina Nikitich
  • Poster: Immune Response Template for Quantitative Systems Pharmacology Modeling: Description of Co-inhibitory and Co-stimulatory Receptors Interaction
    Authors: Antonina Nikitich and Oleg Demin Jr
  • Poster: Modeling of amyloid accumulation in subjects at risk of Alzheimer’s disease under BACE inhibition treatment
    Authors: Etienne Pigeolet1, Konstantinos Biliouris2, Ulf Neumann3, Alexandra Urusova4, Oleg Demin4 and Tatiana Karelina4
    Affiliation: 1Novartis Pharma AG, Basel, Switzerland; 2Novartis Institute for Biomedical Research, Cambridge, USA; 3Novartis Institute for Biomedical Research, Basel, Switzerland; 4InSysBio, Moscow, Russia

ASCPT 2018, Orlando, FL, USA

  • Poster: PBPK modeling for therapeutic nanoparticles loaded with drug: distribution and release
    Authors: Evgeny Metelkin and Oleg Demin
  • Poster: Translational QSP model of amyloid beta allows to predict both short and long term response of AD patients to different therapies
    Authors: Tatiana Karelina1, Oleg Demin1, Oleg Demin Jr1, Timothy Nicholas2
    Affiliation: 1InSysBio, Moscow, Russia; 2Pfizer global R&D, Groton, CT, USA
  • Poster: Multiple myeloma quantitative systems pharmacology model: development and usage for pomalidomide influence evaluation
    Authors: Svetlana Rubina, Oleg Demin and Oleg Demin Jr
  • Poster: Quantitative Systems pharmacology model of bispecific antibodies and CAR-T in acute lymphoblastic leukemia
    Authors: Oleg Demin Jr, Antonina Nikitich and Oleg Demin
  • Poster: Different tau pathology variants can be described by unique QSP model structure for therapy outcome prediction
    Authors: Tatiana Karelina1, Alexander Stepanov1, Oleg Demin1, Timothy Nicholas2
    Affiliation: 1InSysBio, Moscow, Russia; 2Pfizer global R&D, Groton, CT, USA

AAT-AD/PD Focus Meeting 2018, Torino, Italy

  • Presentation: In silico implementation of tauopathy transgenic mouse model
    Speaker: Alexander Stepanov

ACoP8, Fort Lauderdale, Florida, US

  • Mechanistic model for the role of the microgliall cells in amyloid accumulation and its modulation by immunotherapy
    Authors: T. Karelina, A. Stepanov, T. Yuraszeck, S Wood
    Poster
  • Tau propagation system pharmacology model based on three-component memory-retrieval system predicts heterogeneous response to immunotherapy in brain regions
    Authors: T. Karelina, A. Stepanov, T. Nicholas
    Poster
  • Development of systems pharmacology model of multiple myeloma
    Authors: S. Rubina, O. Demin Jr., O. Demin
    Poster
  • Mechanistic modeling of natural killer cell dynamics and cytokine production to support systems pharmacology modeling of the immune response
    Authors: O. Demin, M. Benkov, O. Demin Jr.
    Poster
  • A quantitative systems pharmacology model of asthma
    Authors: S. Smirnov, G.Lebedeva, O. Demin, T. Petukhova, L. Cucurull-Sanchez, D. Fairman
    Poster
  • Model-based analysis of clinical assays for assessing the efficacy of vaccines against Respiratory Syncytial Virus (RSV)
    Authors: G.Lebedeva, N. Pakhomov, O. Demin Jr., O.Demin
    Poster
  • Systems pharmacology modeling for optimization of targeted therapy for melanoma
    Authors: D. Shchelokov, O. Demin Jr.
    Poster
  • Mechanistic modeling of co-stimulatory and co-inhibitory surface molecules effect on cell-cell interactions
    Authors: O. Demin Jr.
    Poster
  • Poster: Quantitative systems pharmacology modeling to evaluate and prioritize targets (CD19, CD20, CD22) for bispecific antibodies and CAR-T in acute lymphoblastic leukemia
    Authors: Oleg Demin Jr and Antonina Nikitich
  • Poster: Evaluation of Potential Low-Dose Regimens of Oral Fixed-Dose Combination of Cytidine Deaminase Inhibitor E7727 with Decitabine (ASTX727-LD) to Minimize Decitabine-Mediated Neutropenia in Low-Risk MDS Subjects Using Systems Pharmacology Modeling
    Authors: Antonina Nikitich1, Oleg Demin1, Oleg Demin Jr1, Aram Oganesian2
    Affiliation: 1InSysBio, Moscow, Russia; 2Astex Pharmaceuticals Inc., Pleasanton, CA, USA

Седьмая германо-российская конференция молодых ученых, Москва, Россия

  • SbmlViewer is a visualization tool for systems biology modeling
    Авторы: В. Ткаченко, Е. Метёлкин
    Poster, RG

MCCMB'17 Москва, Россия

  • Mathematical model of multisite Tau protein phosphorylation for prediction of sensitivity to therapeutic interventions.
    Авторы: А. Степанов, Т. Карелина, О. Демин, Н. Маркевич, Т. Николас, С. Дувури.
    Постер

ADPD2017 Вена, Австрия

  • Amyloid toxicity and different mechanisms of action for amyloid-targeted treatments studied by quantitative systems pharmacology model.
    Авторы: Т. Карелина, Т Николас
    Постер

ASCPT2017 Вашингтон, США

  • Chemokine mediated cell migration.
    Авторы: О. Демин, Е. Метёлкин
    Постер PII-032
  • Effect of costimulatory and co-inhibitory surface molecules on processes associated with cell-to-cell interactions.
    Авторы: О. Демин мл., Е. Метёлкин, О. Демин
    Постер PII-034
  • Cytokine production by immune cells.
    Авторы: О. Демин мл., Е. Метёлкин, О. Демин
    Постер PII-035
  • Mechanistic model of mast cell life cycle, activation and release of bioactive molecules designed to support systems pharmacology modeling of the immune response.
    Авторы: Г. Лебедева, С. Смирнов, Е. Метёлкин, О. Демин
    Постер PII-072
  • Mechanistic model of neutrophil cell dynamics and activation to inform systems pharmacology modeling of the immune response.
    Авторы: Г. Лебедева, С. Смирнов, Е. Метёлкин, О. Демин
    Постер PII-073
  • Neutrophils survival in the presence of pro-inflammatory cytokines.
    Авторы: Е. Метёлкин, А. Уваровский, О. Демин
    Постер PII-097
  • Mathematical description of multiple effects of regulatory molecules.
    Авторы: С. Смирнов, Е. Метёлкин, Г. Лебедева, О. Демин
    Постер PII-131

Рекламные буклеты

InSysBio представляет результаты проектов по использованию системно-фармакологического моделирования для разработки лекарств. ISB case studies 2016 booklet A4 online.pdf Лицензия Creative Commons
Вторая часть примеров использования системно-фармакологического моделирования для разработки лекарств от ИСБ. ISB case studies II 2016 booklet A4 online.pdf Лицензия Creative Commons
InSysBio представляет Immune Responce Template. IRT 1.0 2016 booklet A5 online.pdf Лицензия Creative Commons

ACoP 2016, Белвью, штат Вашингтон, США

 

  • Prediction of treatment efficacy of direct antiviral agent combinations in chronic hepatitis C patients using quantitative systems pharmacology modeling approach.
    Subject: HCV, antiviral, drug combinations
    Author: Demin O. Jr
    Poster
  • Quantitative systems pharmacology model of amyloid pathology allows for clinical endpoint prediction and hypothesis testing
    Subject: amyloid pathology,
    Authors: Karelina T., Demin O., Duvvuri S., Nicholas T.
    Poster
  • Mechanistic approach to describe multiple effects of regulatory molecules on cell dynamics process in immune response.
    Subject: modeling techniques, immune response
    Authors: Demin O., Lebedeva G., Smirnov S.
    Poster
  • Exploration of differences between mechanism-based PK/PD and systems pharmacology models.
    Subject: modeling, review
    Author: Demin O.
    Poster
  • Modeling of immune response suppression by hepatitis C virus and nivolumab treatement in chronic hepatitis C patients using quantitative systems pharmacology approach.
    Subject: HCV, antiviral, immune response
    Author: Demin O. Jr
    Poster
  • Immune Response Template for Quantitative Systems Pharmacology Modeling of Immunotherapy in Oncology.
    Subject: immune response, database
    Author: Demin O. Jr, Nikitich A.
    Poster

PAGE 2016, Лиссабон, Португалия

 

  • Development of Immune Response Template for Systems Pharmacology Modeling of Immunotherapy in Oncology.
    Тема: иммунноонкология, база данных
    Авторы: Метёлкин Е., Дёмин О. мл., Никитич А., Демин О.
    Poster
  • Clinical trial simulation and hypothesis testing using amyloid pathology longitudinal translational model.
    Тема: Болезнь Альцгеймера
    Авторы: Карелина Т., Демин О., Дувури С., Николас Т.
    Poster
  • Population PK modeling of RPH-104, novel optimized IL-1 beta trap, and assessment of the immunogenicity effect on pharmacokinetics.
    Тема: популяционное моделирование, болезнь Бехчета, ССЛ
    Авторы: Метёлкин Е., Петухова Т., Демин О., Шипаева Е., Самсонов М., Кроткова А., Лавровский Ю.
    Poster

ASCPT 2016 Annual Meeting, Сан Диего, США

 

  • Analysis of brain pharmacodynamics of gamma-secretase inhibitors using quantitative translational systems pharmacology model
    Тема: болезнь Альцгеймера
    Авторы: Карелина Т., Демин О., Николас Т., Дувури С.
    Постер
  • Systems Pharmacology Model Of Hepatitis C: Implementation Of Immune Response Suppression By Hepatitis C Virus
    Тема: гепатит С
    Авторы: Демин О. мл., Демин О.
    Постер
  • Population modeling study for evaluation of effective and safe dose of RPH-104 for the treatment of Behcet’s syndrome and FMF.
    Тема: популяционное моделирование, болезнь Бехчета, ССЛ
    Авторы: Метёлкин Е., Петухова Т., Демин О., Шипаева Е., Самсонов М., Кроткова А., Лавровский Ю.
    Постер
  • Simulation of longitudinal tau species behavior during different therapies using quantitative systems pharmacology model
    Тема: болезнь Альцгеймера
    Авторы: Карелина Т., Демин О., Степанов А., Маркевич Н., Синцов А., Николас Т., Дувури С.
    Постер
  • Systems Pharmacology Model Of Hepatitis C: Implementation Of Immune Response Suppression By Hepatitis C Virus
    Тема: гепатит С
    Авторы: Демин О. мл., Демин О.
    Постер
  • Systems Pharmacology Model Of Hepatitis C: Exploration Of Effect Of Combinations Of Direct Antiviral Agents On HCV Production During Treatment Of HCV Patients
    Тема: гепатит С
    Авторы: Демин О. мл., Демин О.
    Постер
  • Systems Pharmacology Model Of Hepatitis C: Prediction Of Results Of Ongoing Clinical Trials Of Direct Antiviral Agents Combination Therapies
    Тема: гепатит С
    Авторы: Демин О. мл., Демин О.
    Постер
  • Population modeling and simulation of RPH-203 effects in the context of prevention of skeletal-related events in patients with bone metastases
    Тема: онкология, популяционное моделирование, матастазы
    Авторы: Метёлкин Е., Петухова Т., Демин О., Арчуадзе Ш., Коноплева Г., Колода Д., Самсонов М.
    Постер
  • Development Of Immune Response Template For Systems Pharmacology Modelling Of Immunotherapy In Oncology
    Тема: гепатит С
    Авторы: Демин О. мл., Никитич А., Демин О.
    Постер
  • Prediction Of Sofosbuvir Active Compound Dynamics In Human Liver In Vivo During Treatment
    Тема: гепатит С
    Авторы: Демин О. мл., Демин О.
    Постер

EMBL-EBI Industry Systems Pharmacology Workshop 2014, Кембридж, Великобритания.

 

  • Systems pharmacology modeling in drug research and development: application of modeling technique
    Тема: методология моделирования
    Автор: Демин О.
    Презентация

Systems Pharmacology in Drug Discovery & Development 2014, Нордвейкерхаут, Голландия

 

  • Systems pharmacology model of amyloid pathology predicts different rates of progression to the same median state for the different patient populations
    Тема: болезнь Альцгеймера, амилоид
    Авторы: Карелина Т., Дувури С., Николас Т., Демин О.
    Постер, Тезисы
  • A systems pharmacology model of purine metabolism to explore novel options for the treatment of Gout
    Тема: подагра
    Авторы: Дуа П., Демин О. мл., Соколов В., Яковлева Т., Демин О., Ван дер Граф П.
    Постер

ASCPT Annual Meeting 2014, Атланта, США

 

  • Systems Pharmacology Modeling of Calcium and Phosphate Metabolism in Chronic Kidney Disease
    Тема: CKD-MBD
    Авторы: Бахмутова А., Демин О.О., Демин О.
    Презентация
  • Investigation of Dapagliflozin Inhibition Effect on Glucose Reabsorption Using Systems Pharmacology Approach
    Тема: SGLT2 ингибиторы, диабет
    Авторы: Яковлева Т., Демин О.О., Демин О.
    Презентация
  • Development and Application of Systems Pharmacology Model to Predict Nausea Resulted from Administration GLP-1 Agonists
    Тема: GLP1 агонисты, тошнота
    Авторы: Воронова В., Демин О.О., Демин О.
    Презентация

American Conference on Pharmacometrics (ACoP) 2013, Форт Лаудердейл, США

 

  • Development of a Human System Pharmacology Model to Characterize Diabetic Nephropathy Disease Progression and the Effect of Standard of Care Therapy
    Тема: диабетическая нефропантия
    Авторы: Чен Д., Воронова В., Смирнов С., Метелкин Е., Горячева Е., Бахмутова А., Демин О.
    Постер

ASCPT Annual Meeting 2013, Индианаполис, США

 

  • Systems Pharmacology Modeling in Research and Development
    Тема: Zeliuton, Целиакия
    Автор: Дёмин О.
    Скачать презентацию
  • Exploration of molecular mechanisms underlying susceptibility of HCV patients to IFN-? therapy via systems pharmacology modeling
    Тема: Гепатит C
    Авторы: Смирнов С., Бенсон Н., Ван Дер Грааф П., Флорес В., Горячева Е., Дёмин О.
    Постер
  • Amyloid Beta Distribution: Detailed Kinetic Model for Mouse scaled to monkey and human
    Тема: болезнь Альцгеймера
    Авторы: Карелина Т., Казимирова Е., Дёмин О., Лу Ю., Николас Т., Дувури С., Бартон Х.
    Скачать постер, Тезисы

IV Съезд биофизиков России 2012, Нижний Новгород, Россия

DMDG meeting 2012, Лафборо, Англия

ICSB 2011, Хайдельберг/Мангейм, Германия

  • Prediction of the outcome of the PEG-IFN treatment of HCV using a viral dynamics model combined with population PK-PD methods
    Тема: гепатит C
    Авторы: Виноградова С., Жуденков К., Дёмин О., Бенсон Н., Ван Дер Грааф П., Карелина Т.
    Скачать тезисы, постер
  • Kinetic modeling of Escherichia coli central carbon metabolism
    Тема: Ecoli, центральный метаболизм
    Авторы: Песков К., Могилевская Е., Дёмин О.
    Скачать тезисы, постер

2d Joint NIAID-ISTC Workshop on Bioinformatics Tools and Innovation Through Collaboration 2011, Москва, Россия

PAGE meeting 2011, Афины, Греция

  • A Systems Pharmacology Model of Anandamide Dynamics After FAAH Inhibitor Administration
    Тема: FAAH
    Авторы: Метёлкин Е., Багрова Н., Дёмин О., Benson N.
    Скачать тезисы, постер

EurasiaBio 2010, Москва, Россия

IDDST 2009, Шанхай, Китай

Helmholtz German-Russian Workshop on Systems Biology 2008, Москва, Россия

MCCMB 2007, Москва, Россия

  • System modeling of EphB4/ephrinB2 signaling pathways
    Тема: Эфрины
    Авторы: Демиденко А., Песков К., Дороднов А., Дёмин О., Новлин Д., Крайнов Е., Вичини П., Луу К.
    Скачать постер
  • Modeling in Systems Biology: Progress, Problems and Applications to Biotechnology and Biomedicine
    Тема: Ecoli: пурины, генетическая регуляция
    Автор: Дёмин О.
    Скачать тезисы, презентацию

12-я международная конференция "Математика. Компьютер. Образование." 2006, Дубна, Россия

Systems Biology: redefining BioThermoKinetics 2006, Тракай, Литва

Biomicroworld 2005, Бадахос, Испания

ICSB 2005, Бостон, США

12th International Conference on Intelligent Systems for Molecular Biology 2004, Глазго, Великобритания