Systems biology

Systems biology is a modern interdisciplinary research area that studies living systems, considering their complexity, direct and inverse regulatory mechanisms, and heterogeneity of experimental data. The subjects of the research in this field are usually the gene regulation system, metabolism, cell dynamics, or interactions in cell populations. Today, systems biology includes specific experimental techniques together with a rich theoretical background. Modeling in systems biology is the main tool for analysis and integration of experimental data and for prediction of system behavior, which is difficult to measure experimentally.

Many methods and approaches of theoretical systems biology can be directly translated to the fields of pharmacology and bio-industry. In particular, if it is necessary to simulate or numerically predict the behavior of complex metabolic or cell systems and optimize its characteristics, the systems pharmacology model would be an acceptable alternative to expensive experimental techniques.

Method application:
In pharmacology

  • Analysis of maximal effectiveness of drug targets. Choice and prioritization of targets at the initial stage of drug development;
  • Selection of the optimal inhibition/activation ratio for multiple targets in combination therapy;
  • Analysis of responses in metabolism after modifications of target activities;
  • Analysis of probable adverse effects at the initial stages of clinical trials;
  • Search and analysis of molecular mechanisms of drug (candidates) failures at preclinical or clinical trials;
  • Design of “optimal” experiments for hypothesis testing.

In bio-industry

  • The prognosis of changes in bioreactor responses after probable genetic manipulations in cultivated organisms or changes in conditions;
  • The formulation or search of genetic modifications for strain overproducers;
  • Optimization of the conditions in the bioreactor for maximal productivity.