Presentations and Posters

Promo booklets

Institute for Systems Biology presents a list of case studies on systems pharmacology modeling for drug development. ISB case studies 2016 booklet A4 online.pdf Лицензия Creative Commons
The second series of case studies on systems pharmacology modeling for drug development by ISB. ISB case studies II 2016 booklet A4 online.pdf Лицензия Creative Commons
Institute for Systems Biology presents Immune Responce Template. IRT 1.0 2016 booklet A5 online.pdf Лицензия Creative Commons

ADPD2017 Vienna, Austria

 

  • Amyloid toxicity and different mechanisms of action for amyloid-targeted treatments studied by quantitative systems pharmacology model.
    Authors: T. Karelina, T. Nicholas
    Poster

ASCPT2017 Washington, DC, US

 

  • Chemokine mediated cell migration.
    Authors: O. Demin, E. Metelkin
    Poster PII-032
  • Effect of costimulatory and co-inhibitory surface molecules on processes associated with cell-to-cell interactions.
    Authors: O. Demin Jr, E. Metelkin, O. Demin
    Poster PII-034
  • Cytokine production by immune cells.
    Authors: O. Demin Jr, E. Metelkin, O. Demin
    Poster PII-035
  • Mechanistic model of mast cell life cycle, activation and release of bioactive molecules designed to support systems pharmacology modeling of the immune response.
    Authors: G. Lebedeva, S. Smirnov, E.Metelkin, O. Demin
    Poster PII-072
  • Mechanistic model of neutrophil cell dynamics and activation to inform systems pharmacology modeling of the immune response.
    Authors: G. Lebedeva, S. Smirnov, E. Metelkin, O. Demin
    Poster PII-073
  • Neutrophils survival in the presence of pro-inflammatory cytokines.
    Authors: E. Metelkin, A.Uvarovskii, O. Demin
    Poster PII-097
  • Mathematical description of multiple effects of regulatory molecules.
    Authors: S. Smirnov, E. Metelkin, G. Lebedeva, O. Demin
    Poster PII-131

ACoP 2016, Bellevue, Washington, US

 

  • Prediction of treatment efficacy of direct antiviral agent combinations in chronic hepatitis C patients using quantitative systems pharmacology modeling approach.
    Subject: HCV, antiviral, drug combinations
    Author: Demin O. Jr
    Poster
  • Quantitative systems pharmacology model of amyloid pathology allows for clinical endpoint prediction and hypothesis testing
    Subject: amyloid pathology,
    Authors: Karelina T., Demin O., Duvvuri S., Nicholas T.
    Poster
  • Mechanistic approach to describe multiple effects of regulatory molecules on cell dynamics process in immune response.
    Subject: modeling techniques, immune response
    Authors: Demin O., Lebedeva G., Smirnov S.
    Presentation, Poster
  • Exploration of differences between mechanism-based PK/PD and systems pharmacology models.
    Subject: modeling, review
    Author: Demin O.
    Poster
  • Modeling of immune response suppression by hepatitis C virus and nivolumab treatement in chronic hepatitis C patients using quantitative systems pharmacology approach.
    Subject: HCV, antiviral, immune response
    Author: Demin O. Jr
    Poster
  • Immune Response Template for Quantitative Systems Pharmacology Modeling of Immunotherapy in Oncology.
    Subject: immune response, database
    Author: Demin O. Jr, Nikitich A.
    Poster

PAGE 2016, Lisboa, Portugal

 

  • Development of Immune Response Template for Systems Pharmacology Modeling of Immunotherapy in Oncology.
    Subject: immunooncology, database
    Authors: Metelkin E., Demin O. Jr, Nikitich A., Demin O.
    Poster
  • Clinical trial simulation and hypothesis testing using amyloid pathology longitudinal translational model.
    Subject: Alzheimer
    Authors: Karelina T., Demin O., Duvvuri S., Nicholas T.
    Poster
  • Population PK modeling of RPH-104, novel optimized IL-1 beta trap, and assessment of the immunogenicity effect on pharmacokinetics.
    Subject: population modeling, Behcet, FMF
    Authors: Metelkin E., Petukhova T., Demin O., Shipaeva E., Samsonov M., Krotkova A., Lavrovsky Y.
    Poster

ASCPT 2016 Annual Meeting, San Diego, USA

 

  • Analysis of brain pharmacodynamics of gamma-secretase inhibitors using quantitative translational systems pharmacology model
    Subject: Alzheimer
    Authors: Karelina T., Demin O., Nicholas T., Duvvuri S.
    Poster
  • Systems Pharmacology Model Of Hepatitis C: Implementation Of Immune Response Suppression By Hepatitis C Virus
    Subject: hepatitis C
    Authors: Demin O. Jr, Demin O.
    Poster
  • Population modeling study for evaluation of effective and safe dose of RPH-104 for the treatment of Behcet’s syndrome and FMF.
    Subject: population modeling, Behcet, FMF
    Authors: Metelkin E., Petukhova T., Demin O., Shipaeva E., Samsonov M., Krotkova A., Lavrovsky Y.
    Poster
  • Simulation of longitudinal tau species behavior during different therapies using quantitative systems pharmacology model
    Subject: Alzheimer
    Authors: Karelina T., Demin O., Stepanov A., Markevich N., Sintsov A., Nicholas T., Duvvuri S.
    Poster
  • Systems Pharmacology Model Of Hepatitis C: Implementation Of Immune Response Suppression By Hepatitis C Virus
    Subject: hepatitis C
    Authors: Demin O. Jr, Demin O.
    Poster
  • Systems Pharmacology Model Of Hepatitis C: Exploration Of Effect Of Combinations Of Direct Antiviral Agents On HCV Production During Treatment Of HCV Patients
    Subject: hepatitis C
    Authors: Demin O. Jr, Demin O.
    Poster
  • Systems Pharmacology Model Of Hepatitis C: Prediction Of Results Of Ongoing Clinical Trials Of Direct Antiviral Agents Combination Therapies
    Subject: hepatitis C
    Authors: Demin O. Jr, Demin O.
    Poster
  • Population modeling and simulation of RPH-203 effects in the context of prevention of skeletal-related events in patients with bone metastases
    Subject: oncology, population modeling, metastases
    Authors: Metelkin E., Petukhova T., Demin O., Archuadze S., Konopleva G., Koloda D., Samsonov M.
    Poster
  • Prediction Of Sofosbuvir Active Compound Dynamics In Human Liver In Vivo During Treatment
    Subject: hepatitis C
    Authors: Demin O. Jr, Demin O.
    Poster

EMBL-EBI Industry Systems Pharmacology Workshop 2014, Cambridge, UK.

 

  • Systems pharmacology modeling in drug research and development: application of modeling technique.
    Subject: methodology
    Author: Demin O.
    Presentation

Systems Pharmacology in Drug Discovery & Development 2014, Noordwijkerhout, The Netherlands.

 

  • Systems pharmacology model of amyloid pathology predicts different rates of progression to the same median state for the different patient populations
    Subject: gout
    Authors: Karelina T., Duvvuri S., Nicholas T., Demin O.
    Poster, Abstract
  • A systems pharmacology model of purine metabolism to explore novel options for the treatment of Gout
    Subject: Alzheimer, amyloid
    Authors: Dua ., Demin O.Jr., Sokolov V., Yakovleva T., Demin O., Van der Graaf P.
    Poster

ASCPT Annual Meeting 2014, Atlanta, USA

 

  • Systems Pharmacology Modeling of Calcium and Phosphate Metabolism in Chronic Kidney Disease
    Subject: CKD-MBD
    Authors: Bakhmutova A., Demin O. Jr., Demin O.
    Poster
  • Investigation of Dapagliflozin Inhibition Effect on Glucose Reabsorption Using Systems Pharmacology Approach
    Subject: SGLT2 inhibitors, diabetes
    Authors: Yakovleva T., Demin O. Jr., Demin O.
    Poster
  • Development and Application of Systems Pharmacology Model to Predict Nausea Resulted from Administration GLP-1 Agonists
    Subject: GLP1 agonists, nausea
    Authors: Voroniva V., Demin O. Jr., Demin O.
    Poster

American Conference on Pharmacometrics (ACoP) 2013, Fort Lauderdale, USA

 

  • Development of a Human System Pharmacology Model to Characterize Diabetic Nephropathy Disease Progression and the Effect of Standard of Care Therapy
    Subject: diabetic nephropathy
    Authors: Chen D., Voronova V., Smirnov S., Metelkin E., Goryacheva E., Bahmutova A., Demin O.
    Poster

ASCPT 2013 Annual Meeting, Indianapolis, USA

 

  • Systems Pharmacology Modeling in Research and Development
    Subject: Zeliuton, Celiac disease
    Author: Demin O.
    Presentation
  • Exploration of molecular mechanisms underlying susceptibility of HCV patients to IFN-? therapy via systems pharmacology modeling
    Subject: HCV
    Authors: Smirnov S., Benson N., Van Der Graaf PH., Flores V., Goryacheva E., Demin O.
    Poster

IV Meeting of Russian Biophysicists 2012, Nizhny Novgorod, Russia

 

  • Modeling of neutrophils dynamics in the presence of survival factors (on Russian)
    Subject: Neutrophils Survival
    Authors: Uvarovskii A., Speshilov G., Metelkin E.
    Download materials, abstract, presentation
  • Modeling of SN-38 inhibitor influence on cancer cell cycle (on Russian)
    Subject: Cell Cycle
    Authors: Pavlin S., Metelkin E.
    Download materials, abstract, presentation

ICSB 2011, Heidelberg/Mannheim, Germany

 

  • Prediction of the outcome of the PEG-IFN treatment of HCV using a viral dynamics model combined with population PK-PD methods
    Subject: HCV
    Authors: Vinogradova S.V. , Zhudenkov K.V. , Demin O.V., Benson N. , Van Der Graaf P. H., Karelina T.A.
    Download abstract, poster
  • Kinetic modeling of Escherichia coli central carbon metabolism
    Subject: Ecoli - central metabolism
    Authors: Peskov K.V., Mogilevskaya E.A., Demin O.V.
    Download abstract, poster

2d Joint NIAID-ISTC Workshop on Bioinformatics Tools and Innovation Through Collaboration 2011, Moscow, Russia

 

PAGE meeting 2011, Athens, Greece

 

  • A Systems Pharmacology Model of Anandamide Dynamics After FAAH Inhibitor Administration
    Subject: FAAH
    Authors: Metelkin E., Bagrova N., Demin O., Benson N.
    Download abstract, poster

EurasiaBio 2010, Moscow, Russia

 

  • Theophylline as HDAC – specific antioxidant: Hypothetical mechanism of anti-inflammatory effects in chronic obstructive pulmonary disease
    Subject: Theophylline
    Authors: Kosinsky Y., Mogilevskaya E., Demin O.
    Download poster, link to the website of the conference

IDDST 2009, Shanghai, China

 

Helmholtz German-Russian Workshop on Systems Biology 2008, Moscow, Russia

 

MCCMB 2007, Moscow, Russia

 

  • System modeling of EphB4/ephrinB2 signaling pathways
    Subject: Ephrin
    Authors: Demidenko A., Peskov K., Dorodnov A., Demin O., Nowlin D., Kraynov E., Vicini P., Luu K.
    Download poster
  • Modeling in Systems Biology: Progress, Problems and Applications to Biotechnology and Biomedicine
    Subject: Ecoli: purins, genetic regulation
    Author: Demin O.
    Download abstract, presentation

12 International Conference "Mathematics. Computer. Education." 2006, Dubna, Russia

 

Systems Biology: redefining BioThermoKinetics 2006, Trakai, Lithuania

 

Biomicroworld 2005, Badajoz, Spain

 

ICSB 2005, Boston, USA